MK-677 (Ibutamoren) - Results, Clinical Trials & Reviews 12.5.2016 · MK-677 Effects Increases Bone Density. In a 12 month study conducted on postmenopausal osteoporotic women, 25 mg of MK-677 per day increased bone mineral density and was well tolerated without any significantly concerning side effects [].In a 2 month randomized, double-blind, parallel, placebo-controlled study on 24 healthy obese men (ages 19 …